Of course not. The reference genomes for single-cell transcriptomics and single-cell V(D)J differ significantly, even though they target the same species. In data analysis, the focus and application scenarios of these references differ. Single-cell immunogenomics mainly focuses on V(D)J recombination and clonotypes of immune receptors to understand the diversity, clonal expansion, and immune response of immune cells. Therefore, when constructing a reference genome for single-cell immunogenomics, particular attention should be paid to immune receptor-related genes such as V, D, and J gene annotations and databases. Single-cell transcriptomics, on the other hand, focuses on gene expression across the entire genome to reveal the transcriptional characteristics of different cell types and states. Consequently, when constructing a reference genome for single-cell transcriptomics, consideration must be given to gene annotations and databases across the entire genome.